Pre-Implantation Genetic Diagnosis

Preimplantation genetic diagnosis (PGD), which is carried out within the programs of IVF or IVF/ICSI, is a method use in the detection of genetic anomalies of an embryo before its transfer to the uterine cavity. This test prevents the transmission of some hereditary diseases to a future child.

To check the genetic material of the embryo, a few cells are carefully sampled after fertilization. These cells undergo a variety of tests to check for the presence of many diseases and major health conditions that could significantly impact your child’s quality of life. Pre-implantation genetic diagnosis can help parents to prevent passing on any serious health complications to their children.

This straightforward process is especially recommended for women aged 35 or older, individuals who have chromosomal disorders and those with pre-existing genetic disorders of any kind. Currently, pre-implantation genetic diagnosis can reliably identify more than 100 conditions, which could substantially influence an offspring's quality of life. While some results garnered through PGD might require additional testing, pre-implantation genetic diagnosis is often a recommended place to start. Most importantly, PGD can offer prospective parents peace of mind.

Pre-implantation genetic diagnosis (PGD) is performed in the IVF or IVF/ICSI (Invitro Fertilization / Intracytoplasmic Sperm Injection) programs that IVF-Surrogacy offers. In conjunction with the medical procedures, PGD can prevent the transmission of diseases to a future child as well as a miscarriage. If a woman is susceptible to miscarriage, this procedure is often recommended by our reproductive specialists to ensure only healthy embryos are selected for uterine transfer. Main indicators that PGD is recommended also includes history of miscarriage, and multiple unsuccessful IVF attempts.

PGD is performed on the third day after fertilization has occurred. Chronozones are analyzed to detect certain anomalies that are specific to each type of screening test, such as PGD-5, PGD-9 and others. The choice to utilize a screening procedure falls to the geneticist to determine which type of procedure will be used. Primary screening procedures include: FISH (Fluorescent in situ hybridization) PCR analysis (polymerase chain reaction), and CGH analysis (comparative genomic hybridization). These PGD tests cause no harm with the extraction of cells from the 6-8 cell embryo development stage, as the development continues naturally without adverse side effects. The results of a PGD test enable reproductive specialists the ability to detect chromosomal abnormalities, increases the chances for successful IVF procedures and diminishes the probability of a miscarriage while identifying the gender of a child. For additional information on how PGD procedures will benefit your specific reproductive needs, contact us to learn more.

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